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MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma

11 Aug 2014

Abstract excerpt

Glioblastomas (GBMs) diffusely infiltrate the brain, making complete removal by surgical resection impossible. The mixture of neoplastic and nonneoplastic cells that remain after surgery form the biological context for adjuvant therapeutic intervention and recurrence. We performed RNA-sequencing (RNA-seq) and histological analysis on radiographically guided biopsies taken from different regions of GBM and showed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25114226
DOI: 10.1073/pnas.1405839111

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