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Article

Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygosity.

American journal of human genetics - 5 Jun 2025

Heng Teng Hiang, Walter Klaudia, Huang Qin Qin, Karjalainen Juha, Daly Mark J, Heyne Henrike O, Malawsky Daniel S, Kalantzis Georgios, Finer Sarah, van Heel David A, Martin Hilary C

Abstract excerpt

Genetic association studies have focused on testing additive models in cohorts with European ancestry. Little is known about recessive effects on common diseases, specifically for non-European ancestry. Genes & Health is a cohort of British Pakistani and Bangladeshi individuals with elevated rates of consanguinity and endogamy, making it suitable to study recessive effects. We imputed variants into a genotyped...

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PMID: 40306283
DOI: 10.1016/j.ajhg.2025.03.020
PMCID: PMC12256797

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PNPLA3

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