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Article

Analysis of Zinc and Stromal Immunity in Disuse Osteoporosis: Mendelian Randomization and Transcriptomic Analysis.

Orthopaedic surgery - 1 Nov 2023

Lyu Fei, Wang Li, Jia Yiming, Wang Yuanlin, Qi Haolan, Dai Zhengxu, Zhou Xuyang, Zhu Haoran, Li Bing, Xu Yujing, Liu Jun

Abstract excerpt

OBJECTIVE: Disuse osteoporosis is known to be primarily caused by a lack of exercise. However, the causal relationships between zinc and immunity and disuse osteoporosis remain unknown. This study investigated these relationships and their potential mechanisms. METHODS: This study was an integrative study combining genome-wide association studies and transcriptomics. Two-sample Mendelian randomization analysis...

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Identifiers

PMID: 37752822
DOI: 10.1111/os.13840
PMCID: PMC10622276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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