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Article

The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer

26 Sept 2023

Abstract excerpt

Aberrant androgen receptor (AR) signaling drives prostate cancer (PC), and it is a key therapeutic target. Although initially effective, the generation of alternatively spliced AR variants (AR-Vs) compromises efficacy of treatments. In contrast to full-length AR (AR-FL), AR-Vs constitutively activate androgenic signaling and are refractory to the current repertoire of AR-targeting therapies, which together drive...

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PMID: 37751307
DOI: 10.1172/jci169200

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