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Article

Prognostic impact of IDH mutations in chondrosarcoma.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association - 1 Nov 2022

Nakagawa Makoto, Sekimizu Masaya, Endo Makoto, Kobayashi Eisuke, Iwata Shintaro, Fukushima Suguru, Yoshida Akihiko, Kitabayashi Issay, Ichikawa Hitoshi, Kawai Akira, Nakatani Fumihiko

Abstract excerpt

BACKGROUND: Mutant isocitrate dehydrogenase (IDH) in chondrosarcoma produces the oncometabolite 2-hydroxyglutarate (2-HG) and contributes to malignant progression, and is therefore a potential therapeutic target for chondrosarcoma. Robust historical control data are important in clinical trials of rare cancers such as chondrosarcoma in order to show a clear benefit of new drugs. However, it remains controversial...

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PMID: 34531086
DOI: 10.1016/j.jos.2021.07.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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