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Article

Targeted Next-Generation Sequencing Identifies Molecular and Genetic Events in Dedifferentiated Chondrosarcoma.

Archives of pathology & laboratory medicine - 1 Aug 2021

Lucas Calixto-Hope G, Grenert James P, Horvai Andrew

Abstract excerpt

CONTEXT.—: Dedifferentiated chondrosarcoma is a rare adult bone tumor with a dismal prognosis and is composed of a conventional chondrosarcoma juxtaposed to high-grade nonchondrogenic sarcoma. Dedifferentiated chondrosarcomas may represent tumor progression from a differentiated to a primitive histotype. OBJECTIVE.—: To determine the genetic and molecular events that drive progression from a conventional...

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PMID: 33147331
DOI: 10.5858/arpa.2020-0379-OA

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