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Time-resolved study on signaling pathway of photoactivated adenylate cyclase and its nonlinear optical response.

The Journal of biological chemistry - 1 Nov 2023

Nakasone Yusuke, Murakami Hiroto, Tokonami Shunrou, Oda Takashi, Terazima Masahide

Abstract excerpt

Photoactivated adenylate cyclases (PACs) are multidomain BLUF proteins that regulate the cellular levels of cAMP in a light-dependent manner. The signaling route and dynamics of PAC from Oscillatoria acuminata (OaPAC), which consists of a light sensor BLUF domain, an adenylate cyclase domain, and a connector helix (α3-helix), were studied by detecting conformational changes in the protein moiety. Although...

Topics

Enzyme Activation
Protein Subunits
Oscillatoria
Light
Mutation
Signal Transduction
Bacterial Proteins
Adenylyl Cyclases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37742920
DOI: 10.1016/j.jbc.2023.105285
PMCID: PMC10634658

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