Article
Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells.
The Journal of biological chemistry - 1 Jun 2018
Blain-Hartung Matthew, Rockwell Nathan C, Moreno Marcus V, Martin Shelley S, Gan Fei, Bryant Donald A, Lagarias J Clark
Abstract excerpt
Class III adenylyl cyclases generate the ubiquitous second messenger cAMP from ATP often in response to environmental or cellular cues. During evolution, soluble adenylyl cyclase catalytic domains have been repeatedly juxtaposed with signal-input domains to place cAMP synthesis under the control of a wide variety of these environmental and endogenous signals. Adenylyl cyclases with light-sensing domains have...
Topics
- Adenylyl Cyclases
- Catalytic Domain
- Cyanobacteria
- Cyclic AMP
- Flavins
- Gene Expression Regulation, Enzymologic
- Light
- Mutation
- Photoreceptors, Microbial
- Signal Transduction