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Article

D-2-hydroxyglutarate regulates human brain vascular endothelial cell proliferation and barrier function.

Journal of neuropathology and experimental neurology - 20 Oct 2023

Cao Chuan, Zhang Lingjun, Sorensen Mia D, Reifenberger Guido, Kristensen Bjarne W, McIntyre Thomas M, Lin Feng

Abstract excerpt

Gain-of-function mutations in isocitrate dehydrogenase (IDH) genes result in excessive production of (D)-2-hydroxyglutarate (D-2HG) which intrinsically modifies tumor cell epigenetics and impacts surrounding noncancerous cells through nonepigenetic pathways. However, whether D-2HG has a paracrine effect on endothelial cells in the tumor microenvironment needs further clarification. We quantified microvessel...

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Source

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Identifiers

PMID: 37740942
DOI: 10.1093/jnen/nlad072
PMCID: PMC10588003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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