Mechanism of Mutation in G Protein-Gated Inwardly Rectifying K+ Channel in Familial Hyperaldosteronism-Type III: Residue Fluctuations and Conformational Instability.

Abstract excerpt

Primary aldosteronism (PA) is the most common cause of secondary hypertension and accounts for 5-15% of hypertensive patients. Familial hyperaldosteronism, a monogenic cause of PA, accounts for ~1-5% of cases. Familial hyperaldosteronism type III results from mutations in the KCNJ5 gene, which lead to excessive aldosterone production and hypertension due to dysfunction of the GIRK4 channel in the adrenal gland....

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• G Protein-Coupled Inwardly-Rectifying Potassium Channels
• KCNJ5 gene
• Hyperaldosteronism
• Molecular Dynamics Simulation