Article
The Molecular Mechanism of Opening the Helix Bundle Crossing (HBC) Gate of a Kir Channel.
Scientific reports - 21 Jul 2016
Meng Xuan-Yu, Liu Shengtang, Cui Meng, Zhou Ruhong, Logothetis Diomedes E
Abstract excerpt
Inwardly rectifying K(+) (Kir) channels, serving as natural molecular nanomachines, transport potassium ions across the plasma membrane of the cell. Along the ion permeation pathway, three relatively narrow regions (the selectivity filter (SF), the inner helix bundle crossing (HBC), and the cytosolic G loop) may serve as gates to control ion permeation. Our previous molecular dynamics simulations based on the...
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