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Article

Genetically determined thymic function affects strength and duration of immune response in COVID patients with pneumonia.

Science advances - 22 Sept 2023

Roux Hélène M, Marouf Amira, Dutrieux Jacques, Charmeteau-De Muylder Bénédicte, Figueiredo-Morgado Suzanne, Avettand-Fenoel Véronique, Cuvelier Pelagia, Naudin Cécile, Bouaziz Fatma, Geri Guillaume, Couëdel-Courteille Anne, Squara Pierre, Marullo Stefano, Cheynier Rémi

Abstract excerpt

Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. The rs2204985 genetic polymorphism within the TCRA-TCRD locus, which affects thymic output in healthy individuals, was found here to modify SARS-CoV-2-specific immunity and disease severity in COVID-19 patients with severe pneumonia. Forty patients with severe COVID-19 pneumonia were investigated. The GG genotype at the rs2204985...

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Identifiers

PMID: 37738336
DOI: 10.1126/sciadv.adh7969
PMCID: PMC10516486

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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