Article
The T-cell repertoire of Spanish patients with COVID-19 as a strategy to link T-cell characteristics to the severity of the disease.
Human genomics - 4 Sept 2024
Marín-Benesiu Fernando, Chica-Redecillas Lucia, Arenas-Rodríguez Verónica, de Santiago Esperanza, Martínez-Diz Silvia, López-Torres Ginesa, Cortés-Valverde Ana Isabel, Romero-Cachinero Catalina, Entrala-Bernal Carmen, Fernandez-Rosado Francisco Javier, Martínez-González Luis Javier, Alvarez-Cubero Maria Jesus
Abstract excerpt
BACKGROUND: The architecture and dynamics of T cell populations are critical in orchestrating the immune response to SARS-CoV-2. In our study, we used T Cell Receptor sequencing (TCRseq) to investigate TCR repertoires in 173 post-infection COVID-19 patients. METHODS: The cohort included 98 mild and 75 severe cases with a median age of 53. We amplified and sequenced the TCR β chain Complementary Determining Region...
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