Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus.

doi:10.1126/scitranslmed.aao2966

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Article

Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus.

Science translational medicine - 5 Sept 2018

Clave Emmanuel, Araujo Itauá Leston, Alanio Cécile, Patin Etienne, Bergstedt Jacob, Urrutia Alejandra, Lopez-Lastra Silvia, Li Yan, Charbit Bruno, MacPherson Cameron Ross, Hasan Milena, Melo-Lima Breno Luiz, Douay Corinne, Saut Noémie, Germain Marine, Trégouët David-Alexandre, Morange Pierre-Emmanuel, Fontes Magnus, Duffy Darragh, Di Santo James P, Quintana-Murci Lluis, Albert Matthew L, Toubert Antoine

Abstract excerpt

The thymus is the primary lymphoid organ where naïve T cells are generated; however, with the exception of age, the parameters that govern its function in healthy humans remain unknown. We characterized the variability of thymic function among 1000 age- and sex-stratified healthy adults of the Milieu Intérieur cohort, using quantification of T cell receptor excision circles (TRECs) in peripheral blood T cells as...

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Identifiers

PMID: 30185651
DOI: 10.1126/scitranslmed.aao2966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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