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Article

The corticotropin-releasing factor receptor-2 mediates the motivational effect of opiate withdrawal.

Neuropharmacology - 1 Oct 2013

Rouibi Khalil, Contarino Angelo

Abstract excerpt

Altered motivational processes are key features of drug dependence and withdrawal, yet their neural mechanisms remain largely unknown. The present study shows that genetic disruption of the corticotropin-releasing factor receptor-2 (CRF₂-/-) does not impair motivation for palatable food in drug-naïve mice. However, CRF₂ receptor-deficiency effectively reduces the increase in palatable food-driven motivation...

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Identifiers

PMID: 23707482
DOI: 10.1016/j.neuropharm.2013.05.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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