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Article

Is it time for a new classification of mast cells? What do we know about mast cell heterogeneity?

Immunological reviews - 1 Mar 2018

Frossi Barbara, Mion Francesca, Sibilano Riccardo, Danelli Luca, Pucillo Carlo E M

Abstract excerpt

Mast cells (MCs) are derived from committed precursors that leave the hematopoietic tissue, migrate in the blood, and colonize peripheral tissues where they terminally differentiate under microenvironment stimuli. They are distributed in almost all vascularized tissues where they act both as immune effectors and housekeeping cells, contributing to tissue homeostasis. Historically, MCs were classified into 2...

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PMID: 29431204
DOI: 10.1111/imr.12636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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