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Current insights and future directions of Li-Fraumeni syndrome

15 Oct 2024

Abstract excerpt

Li-Fraumeni syndrome is a rare yet serious hereditary cancer predisposition syndrome, marked by a significant early-life increased risk of developing cancer. Primarily caused by germline mutations in the TP53 tumor suppressor gene, Li-Fraumeni syndrome is associated with a wide range of malignancies. Clinical management of Li-Fraumeni syndrome could be challenging, especially the lifelong surveillance and...

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PMID: 39404911
DOI: 10.1007/s12672-024-01435-w

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