Article
Gastric cancer in individuals with Li-Fraumeni syndrome.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jul 2011
Masciari Serena, Dewanwala Akriti, Stoffel Elena M, Lauwers Gregory Y, Zheng Hui, Achatz Maria Isabel, Riegert-Johnson Douglas, Foretova Lenka, Silva Edaise M, Digianni Lisa, Verselis Sigitas J, Schneider Katherine, Li Frederick P, Fraumeni Joseph, Garber Judy E, Syngal Sapna
Abstract excerpt
PURPOSE: Li-Fraumeni syndrome is a rare hereditary cancer syndrome associated with germline mutations in the TP53 gene. Although sarcomas, brain tumors, leukemias, breast and adrenal cortical carcinomas are typically recognized as Li-Fraumeni syndrome-associated tumors, the occurrence of gastrointestinal neoplasms has not been fully evaluated. In this analysis, we investigated the frequency and characteristics of...
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