Article
Medical guidelines for Li-Fraumeni syndrome 2019, version 1.1.
International journal of clinical oncology - 1 Dec 2021
Kumamoto Tadashi, Yamazaki Fumito, Nakano Yoshiko, Tamura Chieko, Tashiro Shimon, Hattori Hiroyoshi, Nakagawara Akira, Tsunematsu Yukiko
Abstract excerpt
Li-Fraumeni syndrome (LFS) is a hereditary tumor that exhibits autosomal dominant inheritance. LFS develops in individuals with a pathogenic germline variant of the cancer-suppressor gene, TP53 (individuals with TP53 pathogenic variant). The number of individuals with TP53 pathogenic variant among the general population is said to be 1 in 500 to 20,000. Meanwhile, it is found in 1.6% (median value, range of...
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