Article
Spectrum, prevalence, and clinical correlates of PPM1D mutations in patients with clonal hematopoiesis and clonal cytopenias.
Blood advances - 10 Mar 2026
Badar Talha, Marando Ludovica, Latorre Eric, Lasho Terra, Olivia Francyess Denis, Lin Chenyu, McCormick Benjamin J, El Kettani Mobachir, Shah Kashish J, Kusne Yael, Jamy Omer, Diebold Kendall, Coltoff Alexander, Finke Christy, Foran James, Kharfan-Dabaja Mohamed, Fan Yao-Shan, Jiang Liuyan, He Rong, Thomas Miles, Patel Anand, Viswanatha David, Shah Mithun Vinod, Saliba Antoine, Mangaonkar Abhishek, Kirschner Kristina, Al-Kali Aref, Gangat Naseema, Litzow Mark, Patnaik Mrinal M
Abstract excerpt
ABSTRACT: TP53 and PPM1D are key regulators of DNA damage response and repair, and somatic mutations in these genes often co-occur in hematopoietic cells, expanding under genotoxic stress. Unlike TP53 mutations, where mechanisms of progression are defined, pathways underlying clonal fitness and transformation in PPM1D mutant cells remain unclear. In collaboration with 5 academic institutions, we analyzed the...
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