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Article

Neuronal Phenotype of col4a1 and col25a1: An Intriguing Hypothesis in Vertebrates Brain Aging.

International journal of molecular sciences - 4 Feb 2022

Leggieri Adele, Attanasio Chiara, Palladino Antonio, de Girolamo Paolo, Lucini Carla, D'Angelo Livia

Abstract excerpt

Collagens are the most abundant proteins in vertebrates and constitute the major components of the extracellular matrix. Collagens play an important and multifaceted role in the development and functioning of the nervous system and undergo structural remodeling and quantitative modifications during aging. Here, we investigated the age-dependent regulation of col4a1 and col25a1 in the brain of the short-lived...

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PMID: 35163698
DOI: 10.3390/ijms23031778
PMCID: PMC8836537

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