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Article

Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site.

Nature communications - 18 Nov 2020

Lee Jaeyong, Worrall Liam J, Vuckovic Marija, Rosell Federico I, Gentile Francesco, Ton Anh-Tien, Caveney Nathanael A, Ban Fuqiang, Cherkasov Artem, Paetzel Mark, Strynadka Natalie C J

Abstract excerpt

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen that causes the disease COVID-19, produces replicase polyproteins 1a and 1ab that contain, respectively, 11 or 16 nonstructural proteins (nsp). Nsp5 is the main protease (Mpro) responsible for cleavage at eleven positions along these polyproteins, including at its own N- and C-terminal boundaries, representing essential processing events...

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Identifiers

PMID: 33208735
DOI: 10.1038/s41467-020-19662-4
PMCID: PMC7674412

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