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Article

Impact of Early Pandemic Stage Mutations on Molecular Dynamics of SARS-CoV-2 Mpro.

Journal of chemical information and modeling - 26 Oct 2020

Sheik Amamuddy Olivier, Verkhivker Gennady M, Tastan Bishop Özlem

Abstract excerpt

A new coronavirus (SARS-CoV-2) is a global threat to world health and economy. Its dimeric main protease (Mpro), which is required for the proteolytic cleavage of viral precursor proteins, is a good candidate for drug development owing to its conservation and the absence of a human homolog. Improving our understanding of Mpro behavior can accelerate the discovery of effective therapies to reduce mortality....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32853525
DOI: 10.1021/acs.jcim.0c00634
PMCID: PMC7496595

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