Article

H172Y mutation perturbs the S1 pocket and nirmatrelvir binding of SARS-CoV-2 main protease through a nonnative hydrogen bond

2022-08-09

Abstract excerpt

<title>Abstract</title> <p>Nirmatrelvir is an orally available inhibitor of SARS-CoV-2 main protease (Mpro) and the main ingredient of PAXLOVID, a drug approved by FDA for high-risk COVID- 19 patients. Although the prevalent Mpro mutants in the SARS-CoV-2 Variants of Concern (e.g., Omicron) are still susceptible to nirmatrelvir, a rare mutation, H172Y, was found to significantly reduce nirmatrelvir’s inhibitory a...

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Literature Corpus work: a9f3e084-543c-5bfc-a0bc-48f375df0eee
DOI: 10.21203/rs.3.rs-1915291/v1

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