Article
Precise Correction of Lhcgr Mutation in Stem Leydig Cells by Prime Editing Rescues Hereditary Primary Hypogonadism in Mice.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Oct 2023
Xia Kai, Wang Fulin, Tan Zhipeng, Zhang Suyuan, Lai Xingqiang, Ou Wangsheng, Yang Cuifeng, Chen Hong, Peng Hao, Luo Peng, Hu Anqi, Tu Xiang'an, Wang Tao, Ke Qiong, Deng Chunhua, Xiang Andy Peng
Abstract excerpt
Hereditary primary hypogonadism (HPH), caused by gene mutation related to testosterone synthesis in Leydig cells, usually impairs male sexual development and spermatogenesis. Genetically corrected stem Leydig cells (SLCs) transplantation may provide a new approach for treating HPH. Here, a novel nonsense-point-mutation mouse model (LhcgrW495X ) is first generated based on a gene mutation relative to HPH patients....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.