Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Isogenic Human Cell-Based System for MEN1 Syndrome Generated by CRISPR/Cas9 Genome Editing.

International journal of molecular sciences - 8 Nov 2021

Klementieva Natalia, Goliusova Daria, Krupinova Julia, Yanvarev Vladislav, Panova Alexandra, Mokrysheva Natalia, Kiselev Sergey L

Abstract excerpt

Multiple endocrine neoplasia type 1 (MEN1) is a rare tumor syndrome that manifests differently among various patients. Despite the mutations in the MEN1 gene that commonly predispose tumor development, there are no obvious phenotype-genotype correlations. The existing animal and in vitro models do not allow for studies of the molecular genetics of the disease in a human-specific context. We aimed to create a new...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Gene Editing

Share to Induced Pluripotent Stem Cells

Share to Multiple Endocrine Neoplasia Type 1

Share to Mutation

Share to Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34769484
DOI: 10.3390/ijms222112054
PMCID: PMC8584395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Isogenic Human Cell-Based System for MEN1 Syndrome Generated by CRISPR/Cas9 Genome Editing.PMID 34769484Read ↗

Generation of isogenic and homozygous MEN1 mutant cell lines from patient-derived iPSCs using CRISPR/Cas9.Semantic proximity Read ↗

Generation of non-integrated induced pluripotent stem cells from a 59-year-old female with multiple endocrine neoplasia type 1 syndrome.Semantic proximity Read ↗

Creating a patient carried Men1 gene point mutation on wild type iPSCs locus mediated by CRISPR/Cas9 and ssODN.Semantic proximity Read ↗

Transcriptional landscape of a RETC634Y-mutated iPSC and its CRISPR-corrected isogenic control reveals the putative role of EGR1 transcriptional program in the development of multiple endocrine neoplasia type 2A-associated cancers.Semantic proximity Read ↗

Generation of two gene corrected human isogenic iPSC lines (NCATS-CL6104 and NCATS-CL6105) from a patient line (NCATS-CL6103) carrying a homozygous p.R401X mutation in the NGLY1 gene using CRISPR/Cas9.Semantic proximity Read ↗

A functional genetic toolbox for human tissue-derived organoidsSemantic proximity Read ↗

Generation of isogenic models of Angelman syndrome and Prader-Willi syndrome in CRISPR/Cas9-engineered human embryonic stem cellsSemantic proximity Read ↗

Generation of isogenic models of Angelman syndrome and Prader-Willi syndrome in CRISPR/Cas9-engineered human embryonic stem cellsSemantic proximity Read ↗

Genomic Editing Tools to Model Human Diseases with Isogenic Pluripotent Stem CellsSemantic proximity Read ↗

Genome editing of human pluripotent stem cells to generate human cellular disease modelsSemantic proximity Read ↗

<i>In-vitro</i> cellular reprogramming to model gonad development and its disordersSemantic proximity Read ↗

Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.