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Ets1 and IL17RA cooperate to regulate autoimmune responses and skin immunity to Staphylococcus aureus

23 Aug 2023

Abstract excerpt

Introduction: Ets1 is a lymphoid-enriched transcription factor that regulates B- and Tcell functions in development and disease. Mice that lack Ets1 (Ets1 KO) develop spontaneous autoimmune disease with high levels of autoantibodies. Naïve CD4 + T cells isolated from Ets1 KO mice differentiate more readily to Th17 cells that secrete IL-17, a cytokine implicated in autoimmune disease pathogenesis. To determine if...

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PMID: 37691956
DOI: 10.3389/fimmu.2023.1208200

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