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Development of cost-effective and fast KIR genotyping by multiplex PCR-SSP.

HLA - 1 Jan 2024

Choi Eun-Jeong, Baek In-Cheol, Park Silvia, Kim Hee-Je, Kim Tai-Gyu

Abstract excerpt

Killer-cell immunoglobulin-like receptors (KIR) control natural killer (NK) cell functions by recognizing HLA molecules and modulating the activity of NK cells. The KIR gene cluster contains polymorphic and highly homologous genes. Diversity of the KIR region is achieved through differences in gene content, allelic polymorphism, and gene copy number, which result in unrelated individuals having different KIR...

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PMID: 37688498
DOI: 10.1111/tan.15191

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