Article
Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.
International journal of immunogenetics - 1 Jun 2010
Tajik N, Shahsavar F, Nasiri M, Radjabzadeh M F
Abstract excerpt
Natural killer (NK) cells eliminate infected and transformed cells while still are self-tolerant. Interactions of the independently segregating Killer cell immunoglobulin-like receptors (KIR) and human leucocyte antigens (HLA) loci play a critical role in NK cell regulation. Different compound KIR-HLA genotypes can impart different thresholds of activation to the NK-cell repertoire and such genotypic variation...
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