Article
KIR typing by non-sequencing methods: polymerase-chain reaction with sequence-specific primers.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012
Ordóñez David, Moraru Manuela, Gómez-Lozano Natalia, Cisneros Elisa, Vilches Carlos
Abstract excerpt
The killer-cell immunoglobulin-like receptors (KIR), which enable NK cells to detect allogeneic target cells and abnormalities in the expression of self-HLA molecules, are encoded by genes that display extensive copy number variation. These variations in the KIR genotype are relevant for multiple aspects of human health, including therapy of cancer. PCR with sequence-specific primers (SSP) is simplest and most...
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