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Article

Requirement of WDR70 for POLE3-mediated DNA double-strand breaks repair.

Science advances - 8 Sept 2023

Mao Xiaobing, Wu Jian, Zhang Qin, Zhang Su, Chen Xiaoshuang, Liu Xueqin, Wei Mingtian, Wan Xiaowen, Qiu Lei, Zeng Ming, Lei Xue, Liu Cong, Han Junhong

Abstract excerpt

H2BK120ub1 triggers several prominent downstream histone modification pathways and changes in chromatin structure, therefore involving it into multiple critical cellular processes including DNA transcription and DNA damage repair. Although it has been reported that H2BK120ub1 is mediated by RNF20/40 and CRL4WDR70, less is known about the underlying regulation mechanism for H2BK120ub1 by WDR70. By using a series...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37682991
DOI: 10.1126/sciadv.adh2358
PMCID: PMC10491287

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