Article
[Functional Analysis of DNA Damage Repair Factor WDR70 and Its Mutation in Ovarian Cancer].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition - 1 Jul 2016
Guo Lian-di, Wang Dan, Yang Fan, Liang Yu-Jia, Yang Xue-Qin, Qin Yi-Yang, Ren Lai-Feng, Zeng Ming, Tang Zi-Zhi, Wang Xiao-Jun, Wang Si, Liu Cong, Lou Jiang-Yan, Chen Jie
Abstract excerpt
OBJECTIVES: To analyze the cellular function of the newly discovered DNA damage repair factor WDR70, and investigate the mutation in ovarian cancer to verify if function loss of the WDR70gene was associated with ovarian cancer. METHODS: The WDR70 gene was silenced by using siRNA technique or overexpressed its wild and mutation type by with lentivirus and plasmid in hunman cells. The subcellular localization and...
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