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Article

Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC.

Nature cancer - 1 Sept 2023

Zhou Xu, An Jingyu, Kurilov Roma, Brors Benedikt, Hu Kai, Peccerella Teresa, Roessler Stephanie, Pfütze Katrin, Schulz Angela, Wolf Stephan, Hohmann Nicolas, Theile Dirk, Sauter Max, Burhenne Jürgen, Ei Shigenori, Heger Ulrike, Strobel Oliver, Barry Simon T, Springfeld Christoph, Tjaden Christine, Bergmann Frank, Büchler Markus, Hackert Thilo, Fortunato Franco, Neoptolemos John P, Bailey Peter

Abstract excerpt

Neoadjuvant chemotherapy can improve the survival of individuals with borderline and unresectable pancreatic ductal adenocarcinoma; however, heterogeneous responses to chemotherapy remain a significant clinical challenge. Here, we performed RNA sequencing (n = 97) and multiplexed immunofluorescence (n = 122) on chemo-naive and postchemotherapy (post-CTX) resected patient samples (chemoradiotherapy excluded) to...

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Identifiers

PMID: 37679568
DOI: 10.1038/s43018-023-00628-6
PMCID: PMC10518256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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