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Mycobacterium bovis BCG dodecin gene codes a functional protein despite of a start codon mutation.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2023

Schwarz Marcos Gustavo Araujo, Correa Paloma Rezende, Almeida Paula Silva Lacerda, Mendonça-Lima Leila

Abstract excerpt

Dodecin is a dodecamer involved in flavin homeostasis, with interesting temperature and osmolarity endurance features in Mycobacterium tuberculosis. A single nucleotide polymorphism in the gene's start codon in BCG, converting ATG to ACG, is predicted to generate a N-terminal shorter isoform, lacking the first 7 amino acids. We previously reported that the shortened recombinant protein has reduced extremophilic...

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PMID: 37672955
DOI: 10.1016/j.tube.2023.102400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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