Article
Proteomic characterization of a second-generation version of the BCGΔBCG1419c vaccine candidate by means of electrospray-ionization quadrupole time-of-flight mass spectrometry.
Pathogens and disease - 16 Jan 2021
Velázquez-Fernández Jesús Bernardino, Ferreira-Souza Gustavo Henrique Martins, Rodríguez-Campos Jacobo, Aceves-Sánchez Michel de Jesús, Bravo-Madrigal Jorge, Vallejo-Cardona Alba Adriana, Flores-Valdez Mario Alberto
Abstract excerpt
Tuberculosis (TB) is the most important infectious disease worldwide, based on the number of new cases and deaths reported by the World Health Organization. Several vaccine candidates against TB have been characterized at preclinical and clinical levels. The BCGΔBCG1419c vaccine candidate, which lacks the BCG1419c gene that encodes for a c-di-GMP phosphodiesterase, provides improved efficacy against chronic TB,...
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