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Article

Functional imaging-guided cell selection for evolving genetically encoded fluorescent indicators.

Cell reports methods - 28 Aug 2023

Lin Chang, Liu Lihao, Zou Peng

Abstract excerpt

Genetically encoded fluorescent indicators are powerful tools for tracking cellular dynamic processes. Engineering these indicators requires balancing screening dimensions with screening throughput. Herein, we present a functional imaging-guided photoactivatable cell selection platform, Faculae (functional imaging-activated molecular evolution), for linking microscopic phenotype with the underlying genotype in a...

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Identifiers

PMID: 37671014
DOI: 10.1016/j.crmeth.2023.100544
PMCID: PMC10475787

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