Article
Discovering naturally processed antigenic determinants that confer protective T cell immunity.
The Journal of clinical investigation - 1 May 2013
Gilchuk Pavlo, Spencer Charles T, Conant Stephanie B, Hill Timothy, Gray Jennifer J, Niu Xinnan, Zheng Mu, Erickson John J, Boyd Kelli L, McAfee K Jill, Oseroff Carla, Hadrup Sine R, Bennink Jack R, Hildebrand William, Edwards Kathryn M, Crowe James E, Williams John V, Buus Søren, Sette Alessandro, Schumacher Ton N M, Link Andrew J, Joyce Sebastian
Abstract excerpt
CD8+ T cells (TCD8) confer protective immunity against many infectious diseases, suggesting that microbial TCD8 determinants are promising vaccine targets. Nevertheless, current T cell antigen identification approaches do not discern which epitopes drive protective immunity during active infection - information that is critical for the rational design of TCD8-targeted vaccines. We employed a proteomics-based...
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