Article
Overview: the maturing of proteomics in cardiovascular research.
Circulation research - 18 Feb 2011
Van Eyk Jennifer E
Abstract excerpt
Proteomic technologies are used to study the complexity of proteins, their roles, and biological functions. It is based on the premise that the diversity of proteins, comprising their isoforms, and posttranslational modifications (PTMs) underlies biology. Based on an annotated human cardiac protein database, 62% have at least one PTM (phosphorylation currently dominating), whereas ≈25% have more than one type of...
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