Article
Distinct Myocardial Transcriptomic Profiles of Cardiomyopathies Stratified by the Mutant Genes.
Genes - 28 Nov 2020
Sielemann Katharina, Elbeck Zaher, Gärtner Anna, Brodehl Andreas, Stanasiuk Caroline, Fox Henrik, Paluszkiewicz Lech, Tiesmeier Jens, Wlost Stefan, Gummert Jan, Albaum Stefan P, Sielemann Janik, Knöll Ralph, Milting Hendrik
Abstract excerpt
Cardiovascular diseases are the number one cause of morbidity and mortality worldwide, but the underlying molecular mechanisms remain not well understood. Cardiomyopathies are primary diseases of the heart muscle and contribute to high rates of heart failure and sudden cardiac deaths. Here, we distinguished four different genetic cardiomyopathies based on gene expression signatures. In this study, RNA-Sequencing...
Topics
- Adult
- Aged
- Cardiomyopathies
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Muscle Proteins
- Mutation
- Myocardium