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Article

Proteomic profiling identifies molecular subtypes and unveils mechanistic insights into clinical features of hypertrophic cardiomyopathy.

Journal of translational medicine - 11 May 2026

Guo Xinli, Song Changpeng, Nie Changrong, Zheng Xinxin, Wang Shuiyun, Huang Xiaohong

Abstract excerpt

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, shows significant genetic and clinical heterogeneity, yet its molecular basis remains unclear. This study aims to uncover molecular insights behind HCM based on proteomic analysis. METHODS: We performed proteomic analysis on formalin-fixed paraffin-embedded septal tissue samples from 105 patients with obstructive HCM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42116078
DOI: 10.1186/s12967-026-08206-x
PMCID: PMC13169720

Genes

MYBPC3
MYH7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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