Article
Proinflammatory phenotype in major depressive disorder with adulthood adversity: In line with social signal transduction theory of depression.
Journal of affective disorders - 15 Nov 2023
Lin Jingyu, Li Ji-Tao, Kong Linghua, Liu Qi, Lv Xiaozhen, Wang Gang, Wei Jing, Zhu Gang, Chen Qiaoling, Tian Hongjun, Zhang Kerang, Wang Xueyi, Zhang Nan, Yu Xin, Si Tianmei, Su Yun-Ai
Abstract excerpt
BACKGROUND: The social signal transduction theory of depression proposes that life stress can be transformed into inflammatory signals, and ultimately lead to the development of major depressive disorder (MDD). The hypotheses of this study were: (1) The pro-inflammatory effect of life stress was only seen in patients with MDD, but not in healthy controls (HCs); (2) Inflammation can mediate the relationship...
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