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In severe first episode major depressive disorder, psychosomatic, chronic fatigue syndrome, and fibromyalgia symptoms are driven by immune activation and increased immune-associated neurotoxicity.

2023-11-07

Abstract excerpt

<h4>Background: </h4> Major depressive disorder (MDD) is accompanied by activated neuro-immune pathways, increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe MDD phenotype, namely major dysmood disorder (MDMD), is associated with adverse childhood experiences (ACEs) and negative life events (NLEs) which induce cytokines/chemokines/growth factors. Aims To delineate the impact of...

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Literature Corpus work
0803f34a-4346-506f-9475-27a817f3a439
DOI
10.21203/rs.3.rs-3527156/v1
Open publication

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In severe first episode major depressive disorder, psychosomatic, chronic fatigue syndrome, and fibromyalgia symptoms are driven by immune activation and increased immune-associated neurotoxicity.DOI 10.21203/rs.3.rs-3527156/v1
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