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Ex vivo treatment with poly (I:C) alleviates the exhausted phenotype of tumor-infiltrating TCD8+ cells of gastric cancer patients.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Feb 2024

Mohammad Talar Ahmad Merza, Hussein Farhad Nehmatullah, Abbas Ashwaq Najemaldeen, Jaafar Halmat M, Salam Brwa Bakr

Abstract excerpt

Gastric cancer is associated with the phenotypic and functional exhaustion of TCD8+ cells. On the other hand, Toll-like receptor (TLR) agonists are known to reinforce immune responses when used as adjuvants in cancer immunotherapies. Since the compromised signaling of pro-inflammatory pathways is usually associated with T cell exhaustion, the aim of the present study was to evaluate the impact of...

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PMID: 37639020
DOI: 10.1007/s00210-023-02689-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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