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Genome wide association study and genomic risk prediction of age related macular degeneration in Israel.

Scientific reports - 6 Jun 2024

Grunin Michelle, Triffon Daria, Beykin Gala, Rahmani Elior, Schweiger Regev, Tiosano Liran, Khateb Samer, Hagbi-Levi Shira, Rinsky Batya, Munitz Refael, Winkler Thomas W, Heid Iris M, Halperin Eran, Carmi Shai, Chowers Itay

Abstract excerpt

The risk of developing age-related macular degeneration (AMD) is influenced by genetic background. In 2016, the International AMD Genomics Consortium (IAMDGC) identified 52 risk variants in 34 loci, and a polygenic risk score (PRS) from these variants was associated with AMD. The Israeli population has a unique genetic composition: Ashkenazi Jewish (AJ), Jewish non-Ashkenazi, and Arab sub-populations. We aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38844476
DOI: 10.1038/s41598-024-63065-0
PMCID: PMC11156861

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