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Article

Epigenetic Inactivation of the Circadian Clock Gene <i>BMAL1</i> in Hematologic Malignancies

27 Oct 2009

Abstract excerpt

Disruption of circadian rhythms, daily oscillations in biological processes that are regulated by an endogenous clock, has been linked to tumorigenesis. Normal and malignant tissues often show asynchronies in cell proliferation and metabolic rhythms. Cancer chronotherapy takes biological time into account to improve the therapy. However, alterations of the circadian clock machinery genes have rarely been reported...

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PMID: 19861541
DOI: 10.1158/0008-5472.can-09-0551

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