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Article

Genomic Instability and DNA Damage Repair Pathways Induced by Human Papillomaviruses.

Viruses - 14 Sept 2021

Kono Takeyuki, Laimins Laimonis

Abstract excerpt

Human papillomaviruses (HPV) are the causative agents of cervical and other anogenital cancers as well as those of the oropharynx. HPV proteins activate host DNA damage repair factors to promote their viral life cycle in stratified epithelia. Activation of both the ATR pathway and the ATM pathway are essential for viral replication and differentiation-dependent genome amplification. These pathways are also...

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Identifiers

PMID: 34578402
DOI: 10.3390/v13091821
PMCID: PMC8472259

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