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Article

The non-deterministic genotype-phenotype map of RNA secondary structure.

Journal of the Royal Society, Interface - 1 Aug 2023

García-Galindo Paula, Ahnert Sebastian E, Martin Nora S

Abstract excerpt

Selection and variation are both key aspects in the evolutionary process. Previous research on the mapping between molecular sequence (genotype) and molecular fold (phenotype) has shown the presence of several structural properties in different biological contexts, implying that these might be universal in evolutionary spaces. The deterministic genotype-phenotype (GP) map that links short RNA sequences to minimum...

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Identifiers

PMID: 37608711
DOI: 10.1098/rsif.2023.0132
PMCID: PMC10445035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The non-deterministic genotype-phenotype map of RNA secondary structure.PMID 37608711Read ↗

A simple model captures key characteristics of biological non-deterministic genotype-phenotype maps.Semantic proximity Read ↗

The organization of biological sequences into constrained and unconstrained parts determines fundamental properties of genotype-phenotype maps.Semantic proximity Read ↗

Using small samples to estimate neutral component size and robustness in the genotype-phenotype map of RNA secondary structure.Semantic proximity Read ↗

Phenotypes can be robust and evolvable if mutations have non-local effects on sequence constraints.Semantic proximity Read ↗

Fast free-energy-based neutral set size estimates for the RNA genotype-phenotype map.Semantic proximity Read ↗

Phenotypic cliffs in the RNA genotype-phenotype map.Semantic proximity Read ↗

Mutational robustness accelerates the origin of novel RNA phenotypes through phenotypic plasticity.Semantic proximity Read ↗

Genetic Correlations Greatly Increase Mutational Robustness and Can Both Reduce and Enhance Evolvability.Semantic proximity Read ↗

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