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Article

Phenotypic cliffs in the RNA genotype-phenotype map.

Journal of the Royal Society, Interface - 22 Apr 2026

García-Galindo Paula, Ahnert Sebastian

Abstract excerpt

Point mutations of a genotype can leave the phenotype unchanged, or change it, in some cases radically. The extent of this phenotypic change can critically impact fitness. To investigate the range of possible phenotypic changes that result from point mutations, we analyse the structure of the well-established RNA genotype-phenotype (GP) map for sequences of length 12 by developing a general phenotypic distance...

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Identifiers

PMID: 42014066
DOI: 10.1098/rsif.2025.1028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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