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Article

Modelling 'evo-devo' with RNA.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Dec 2002

Fontana Walter

Abstract excerpt

The folding of RNA sequences into secondary structures is a simple yet biophysically grounded model of a genotype-phenotype map. Its computational and mathematical analysis has uncovered a surprisingly rich statistical structure characterized by shape space covering, neutral networks and plastogenetic congruence. I review these concepts and discuss their evolutionary implications.

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Identifiers

PMID: 12447981
DOI: 10.1002/bies.10190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modelling 'evo-devo' with RNA.PMID 12447981Read ↗

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The non-deterministic genotype-phenotype map of RNA secondary structure.Semantic proximity Read ↗

The organization of biological sequences into constrained and unconstrained parts determines fundamental properties of genotype-phenotype maps.Semantic proximity Read ↗

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Reconstruction of natural RNA sequences from RNA shape, thermodynamic stability, mutational robustness, and linguistic complexity by evolutionary computation.Semantic proximity Read ↗

Epistasis can lead to fragmented neutral spaces and contingency in evolution.Semantic proximity Read ↗

Topological structure of the space of phenotypes: the case of RNA neutral networks.Semantic proximity Read ↗

Phenotype Bias Determines How Natural RNA Structures Occupy the Morphospace of All Possible Shapes.Semantic proximity Read ↗

Insertions and deletions in the RNA sequence-structure map.Semantic proximity Read ↗

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Generic properties of combinatory maps: neutral networks of RNA secondary structures.Semantic proximity Read ↗

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