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Article

Genetic Correlations Greatly Increase Mutational Robustness and Can Both Reduce and Enhance Evolvability.

PLoS computational biology - 1 Mar 2016

Greenbury Sam F, Schaper Steffen, Ahnert Sebastian E, Louis Ard A

Abstract excerpt

Mutational neighbourhoods in genotype-phenotype (GP) maps are widely believed to be more likely to share characteristics than expected from random chance. Such genetic correlations should strongly influence evolutionary dynamics. We explore and quantify these intuitions by comparing three GP maps-a model for RNA secondary structure, the HP model for protein tertiary structure, and the Polyomino model for protein...

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PMID: 26937652
DOI: 10.1371/journal.pcbi.1004773
PMCID: PMC4777517

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